Stimuli-responsive Crosslinked Chitosan/Polyethylene glycol/3-Glycidyloxypropyltrimethoxy silane-based Hydrogels for Biomedical Applications
DOI:
https://doi.org/10.37155/2972-449X-vol2(1)-102Keywords:
Hydrogel, Chitosan, Wound dressing, Polyethylene glycol, Thermogravimetric analysis, Swelling, 3-Glycidyloxypropyltrimethoxy silaneAbstract
Biodegradable pH-responsive hydrogels have become a powerful tool in medicine for synthesizing wound dressings and drug delivery applications. The current study focuses on the development of crosslinked semi-interpenetrating polymer networks of chitosan/poly(ethylene glycol)/3-glycidyloxypropyltrimethoxy silane (GPTMS) blends containing honey and aloe vera gel. All hydrogels were prepared by physical blending and solution casting methods. Fourier transform infrared (FTIR) spectroscopy was performed to analyse the developed interactions among the polymers and crosslinker. To check the thermal behaviour and crosslinking density of all hydrogel matrixes, thermogravimetric analysis (TGA) was done. The effects of the crosslinker concentration on the swelling trend of all hydrogels were investigated against distilled water and buffers of varying pH. The hydrogels were found thermally stable with enhanced swelling rate, good moisture capability, and pH responsiveness. These properties and the material's cost-effectiveness suggest that the fabricated blend hydrogels can be suitable for wound dressing and other biomedical applications.
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