Stimuli-responsive Crosslinked Chitosan/Polyethylene glycol/3-Glycidyloxypropyltrimethoxy silane-based Hydrogels for Biomedical Applications


  • Sehrish Hanif Institutes of Polymer and Textile Engineering, University of Punjab, Lahore, 54590, Pakistan.
  • Shabnam Rehmat Department of Chemistry, University of Narowal, Narowal, 51600, Pakistan; School of Chemistry, University of the Punjab, Lahore, 54590, Pakistan.
  • Mehboob Hassan Department of Chemistry, University of Narowal, Narowal, 51600, Pakistan.
  • Fiza Majeed Department of Chemistry, University of Narowal, Narowal, 51600, Pakistan.
  • Atif Islam Institutes of Polymer and Textile Engineering, University of Punjab, Lahore, 54590, Pakistan.
  • Rafi Ullah Khan Institutes of Polymer and Textile Engineering, University of Punjab, Lahore, 54590, Pakistan.



Hydrogel, Chitosan, Wound dressing, Polyethylene glycol, Thermogravimetric analysis, Swelling, 3-Glycidyloxypropyltrimethoxy silane


Biodegradable pH-responsive hydrogels have become a powerful tool in medicine for synthesizing wound dressings and drug delivery applications. The current study focuses on the development of crosslinked semi-interpenetrating polymer networks of chitosan/poly(ethylene glycol)/3-glycidyloxypropyltrimethoxy silane (GPTMS) blends containing honey and aloe vera gel. All hydrogels were prepared by physical blending and solution casting methods. Fourier transform infrared (FTIR) spectroscopy was performed to analyse the developed interactions among the polymers and crosslinker. To check the thermal behaviour and crosslinking density of all hydrogel matrixes, thermogravimetric analysis (TGA) was done. The effects of the crosslinker concentration on the swelling trend of all hydrogels were investigated against distilled water and buffers of varying pH. The hydrogels were found thermally stable with enhanced swelling rate, good moisture capability, and pH responsiveness. These properties and the material's cost-effectiveness suggest that the fabricated blend hydrogels can be suitable for wound dressing and other biomedical applications.


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How to Cite

Hanif, S., Rehmat, S., Hassan, M., Majeed, F., Islam, A., & Rafi Ullah Khan. (2024). Stimuli-responsive Crosslinked Chitosan/Polyethylene glycol/3-Glycidyloxypropyltrimethoxy silane-based Hydrogels for Biomedical Applications. BME Horizon, 2(1).