Photoacoustic Imaging an Emerging Technique for Biomedical Imaging

Authors

  • Sudip Mondal Smart Gym-Based Translational Research Center for Active Senior’s Healthcare, Pukyong National University, Busan 48513, Republic of Korea.
  • Sumin Park Industry 4.0 Convergence Bionics Engineering, Department of Biomedical Engineering, Pukyong National University, Busan 48513, Republic of Korea.
  • Jaeyeop Choi Smart Gym-Based Translational Research Center for Active Senior’s Healthcare, Pukyong National University, Busan 48513, Republic of Korea.
  • Junghwan Oh Smart Gym-Based Translational Research Center for Active Senior’s Healthcare, Pukyong National University, Busan 48513, Republic of Korea. Industry 4.0 Convergence Bionics Engineering, Department of Biomedical Engineering, Pukyong National University, Busan 48513, Republic of Korea. Ohlabs Corp., Busan 48513, Republic of Korea.

DOI:

https://doi.org/10.37155/2972-449X-0101-4

Keywords:

Photoacoustic imaging (PAI), Nanomaterials, Bioimaging, Cancer diagnosis, Tumor imaging

Abstract

Photoacoustic imaging (PAI) is a rapidly growing biomedical imaging technique that combines the advantages of optical and acoustic imaging. This technique utilizes pulsed laser light to generate acoustic waves in biological tissue, which are then detected and used to create high-resolution images of tissue structure and function. PAI has several advantages over other imaging modalities, including its ability to provide functional information about tissue properties such as blood oxygenation and blood flow, as well as its ability to image tissue at greater depths than many other techniques. However, there are also challenges associated with PAI, including the need for specialized equipment and concerns regarding the potential for tissue damage due to laser exposure. Despite these challenges, PAI is a promising technique with many potential applications in biomedical research and clinical practice, and ongoing research in this area is likely to yield further advances in the coming years.

References

Su Y, Zhang F, Xu K, et al. A photoacoustic tomography system for imaging of biological tissues. Journal of Physics D: Applied Physics, 2005;38(15):2640.

Lungu GF, Li M-L, Xie X, et al. In vivo imaging and characterization of hypoxia-induced neovascularization and tumor invasion. International journal of oncology, 2007;30(1):45-54.

Wang LV, Gao L. Photoacoustic microscopy and computed tomography: from bench to bedside. Annual review of biomedical engineering, 2014;16:155-85.

Lin L, Hu P, Tong X, et al. High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation. Nature Communications, 2021;12(1):882.

Hu S, Wang Lihong V. Optical-Resolution Photoacoustic Microscopy: Auscultation of Biological Systems at the Cellular Level. Biophysical journal, 2013;105(4):841-7.

Yao J, Wang LV. Photoacoustic microscopy. Laser & photonics reviews, 2013;7(5):758-78.

Das D, Sharma A, Rajendran P, et al. Another decade of photoacoustic imaging. Physics in Medicine & Biology, 2021;66(5):05TR1.

Pham VH, Nguyen VT, Ly CD, et al. Development of fast photoacoustic and ultrasound imaging system based on slider-crank scanner for small animals and humans study. Expert Systems with Applications, 2022;206:117939.

Kim C, Favazza C, Wang LV. In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. Chemical reviews, 2010;110(5):2756-82.

Xie Z, Jiao S, Zhang HF, et al. Laser-scanning optical-resolution photoacoustic microscopy. Optics letters, 2009;34(12):1771-3.

Nguyen VT, Truong NTP, Pham VH, et al. Ultra-widefield photoacoustic microscopy with a dual-channel slider-crank laser-scanning apparatus for in vivo biomedical study. Photoacoustics, 2021;23:100274.

Mallidi S, Luke GP, Emelianov S. Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance. Trends in biotechnology, 2011;29(5):213-21.

Ly CD, Nguyen VT, Vo TH, et al. Full-view in vivo skin and blood vessels profile segmentation in photoacoustic imaging based on deep learning. Photoacoustics, 2022;25:100310.

Rajian JR, Carson PL, Wang X. Quantitative photoacoustic measurement of tissue optical absorption spectrum aided by an optical contrast agent. Optics express, 2009;17(6):4879-89.

Wong TTW, Zhang R, Zhang C, et al. Label-free automated three-dimensional imaging of whole organs by microtomy-assisted photoacoustic microscopy. Nature Communications, 2017;8(1):1386.

Xiang L, Wang B, Ji L, et al. 4-D photoacoustic tomography. Scientific reports, 2013;3(1):1113.

Zhang Q, Liu Z, Carney PR, et al. Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography. Physics in Medicine & Biology, 2008;53(7):1921.

Li Y, Chen Y, Du M, et al. Ultrasound technology for molecular imaging: from contrast agents to multimodal imaging. ACS Biomaterials Science & Engineering, 2018;4(8):2716-28.

Ntziachristos V, Razansky D. Molecular imaging by means of multispectral optoacoustic tomography (MSOT). Chemical reviews, 2010;110(5):2783-94.

Lin L, Wang LV. The emerging role of photoacoustic imaging in clinical oncology. Nature Reviews Clinical Oncology, 2022;19(6):365-84.

James S, Neuhaus K, Murphy M, et al. Contrast agents for photoacoustic imaging: a review of stem cell tracking. Stem Cell Research & Therapy, 2021;12(1):511.

Weber J, Beard PC, Bohndiek SE. Contrast agents for molecular photoacoustic imaging. Nature methods, 2016;13(8):639-50.

Lemaster JE, Jokerst JV. What is new in nanoparticle‐based photoacoustic imaging? Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2017;9(1):e1404.

Cheheltani R, Ezzibdeh RM, Chhour P, et al. Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging. Biomaterials, 2016;102:87-97.

Mondal S, Montaño-Priede JL, Nguyen VT, et al. Computational analysis of drug free silver triangular nanoprism theranostic probe plasmonic behavior for in-situ tumor imaging and photothermal therapy. Journal of Advanced Research, 2022;41:23-38.

Xi L, Grobmyer SR, Zhou G, et al. Molecular photoacoustic tomography of breast cancer using receptor targeted magnetic iron oxide nanoparticles as contrast agents. Wiley Online Library, 2014. p. 401-9.

Fu Q, Zhu R, Song J, et al. Photoacoustic imaging: contrast agents and their biomedical applications. Advanced Materials, 2019;31(6):1805875.

Upputuri PK, Pramanik M. Recent advances in photoacoustic contrast agents for in vivo imaging. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2020;12(4):e1618.

Filippi M, Garello F, Pasquino C, et al. Indocyanine green labeling for optical and photoacoustic imaging of mesenchymal stem cells after in vivo transplantation. Journal of Biophotonics, 2019;12(5):e201800035.

Donnelly EM, Kubelick KP, Dumani DS, et al. Photoacoustic Image-Guided Delivery of Plasmonic-Nanoparticle-Labeled Mesenchymal Stem Cells to the Spinal Cord. Nano Letters, 2018;18(10):6625-32.

Kubelick KP, Snider EJ, Ethier CR, et al. Development of a stem cell tracking platform for ophthalmic applications using ultrasound and photoacoustic imaging. Theranostics, 2019;9(13):3812-24.

Jokerst JV, Thangaraj M, Kempen PJ, et al. Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods. ACS Nano, 2012;6(7):5920-30.

Comenge J, Fragueiro O, Sharkey J, et al. Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. ACS Nano, 2016;10(7):7106-16.

Dhada KS, Hernandez DS, Suggs LJ. In Vivo Photoacoustic Tracking of Mesenchymal Stem Cell Viability. ACS Nano, 2019;13(7):7791-9.

Qiao Y, Gumin J, MacLellan CJ, et al. Magnetic resonance and photoacoustic imaging of brain tumor mediated by mesenchymal stem cell labeled with multifunctional nanoparticle introduced via carotid artery injection. Nanotechnology, 2018;29(16):165101.

Zhang YS, Wang Y, Wang L, et al. Labeling Human Mesenchymal Stem Cells with Gold Nanocages for in vitro and in vivo Tracking by Two-Photon Microscopy and Photoacoustic Microscopy. Theranostics, 2013;3(8):532-43.

Adjei IM, Yang H, Plumton G, et al. Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells. Drug Delivery and Translational Research, 2019;9(3):652-66.

Lemaster JE, Chen F, Kim T, et al. Development of a Trimodal Contrast Agent for Acoustic and Magnetic Particle Imaging of Stem Cells. ACS Applied Nano Materials, 2018;1(3):1321-31.

Zhang H, Wang Z-J, Wang L-J, et al. A dual-mode nanoparticle based on natural biomaterials for photoacoustic and magnetic resonance imaging of bone mesenchymal stem cells in vivo. RSC Advances, 2019;9(60):35003-10.

Li W, Chen R, Lv J, et al. In Vivo Photoacoustic Imaging of Brain Injury and Rehabilitation by High-Efficient Near-Infrared Dye Labeled Mesenchymal Stem Cells with Enhanced Brain Barrier Permeability. Advanced Science, 2018;5(2):1700277.

Kim T, Lemaster JE, Chen F, et al. Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue–Poly(l-lysine) Nanocomplexes. ACS Nano, 2017;11(9):9022-32.

Yin C, Wen G, Liu C, et al. Organic Semiconducting Polymer Nanoparticles for Photoacoustic Labeling and Tracking of Stem Cells in the Second Near-Infrared Window. ACS Nano, 2018;12(12):12201-11.

Lemaster JE, Wang Z, Hariri A, et al. Gadolinium Doping Enhances the Photoacoustic Signal of Synthetic Melanin Nanoparticles: A Dual Modality Contrast Agent for Stem Cell Imaging. Chemistry of Materials, 2019;31(1):251-9.

Van Eck N, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. scientometrics, 2010;84(2):523-38.

Downloads

Published

14-06-2023

How to Cite

Mondal, S., Park, S., Choi, J., & Oh, J. (2023). Photoacoustic Imaging an Emerging Technique for Biomedical Imaging. BME Horizon, 1(1). https://doi.org/10.37155/2972-449X-0101-4

Issue

Section

Perspective